Stress : Either physical injury or emotional disturbance is frequently blamed as the initial cause of the disease. Any disturbance in Corticosteroid or ACTH therapy may lead to clinical signs of the diseases.


Drug Induced: Clozapine (Clozaril), olanzapine (Zyprexa), risperidone (Risperdal), quetiapine (Seroquel) and ziprasidone (Geodon) are known to induce this lethal disease.


Infection : Some of the strephylococci are suppose to be responsible factor for infection in pancreas.


Sex : It is commonly seen in elderly especially males but strong evidence of developing diabetes in females with multiple pregnancy has been observed or in females suffering from (PCOS) Polycystic Ovarian Syndrome.


Hypertension : It had been reported in many studies that there is direct relation between high systolic pressure and diabetes.


Serum lipids and lipoproteins : High triglyceride and cholesterol level in the blood are related to high blood sugars, in some cases it had been studied that risk are involved even with low HDL levels in circulating blood.